N-Terminal Acetyltransferase C (NatC) Complex: A Drug Target and Biomarker

Target Name: N-Terminal Acetyltransferase C (NatC) Complex

NCBI ID: P26771

N-Terminal Acetyltransferase C (NatC) Complex

Other Name(s): NatC

N-Terminal Acetyltransferase C (NatC) Complex: A Drug Target and Biomarker

N-Terminal Acetyltransferase C (NatC) complex is a protein that plays a crucial role in cellular processes such as DNA replication, transcription, and cell growth. The NatC complex is composed of multiple proteins that work together to transfer acetyl groups to specific amino acids on the N-termini of incoming proteins. This complex is highly conserved across various species, and its function is essential for the proper functioning of many cellular processes.

The NatC complex is also known as the DNA replication complex V, and it is a key player in the process of DNA replication. In DNA replication, the NatC complex helps to ensure that the four DNA strands are properly copied and that any errors or mutations are properly repaired. This is critical for the maintenance of genetic accuracy and for the development and maintenance of a healthy cell.

In addition to its role in DNA replication, the NatC complex is also involved in the regulation of gene expression. It has been shown to play a role in the transfer of acetyl groups to specific amino acids on the N-termini of proteins, which can influence protein stability, localization, and interactions with other cellular components. This regulation of protein acetylation is critical for the proper functioning of many cellular processes, including cell signaling, cell division, and metabolism.

The NatC complex is also a potential drug target and biomarker. Its role in the regulation of DNA replication and gene expression makes it an attractive target for the development of cancer therapies. Additionally, the NatC complex is highly conserved across various species, which makes it a useful tool for the study of protein function and evolution.

The discovery of the NatC complex and its functions has been the result of many years of research, and it has led to a greater understanding of the complex mechanisms underlying protein regulation. The study of the NatC complex has also led to the development of new technologies for the analysis of protein structure and function, such as homology modeling and site-directed mutagenesis.

In conclusion, the N-Terminal Acetyltransferase C (NatC) complex is a protein that plays a crucial role in the regulation of DNA replication and gene expression. Its functions make it an attractive target for the development of cancer therapies, and its study has led to a greater understanding of the complex mechanisms underlying protein regulation. Further research on the NatC complex is likely to uncover its full potential as a drug target and biomarker.

Protein Name: N-Terminal Acetyltransferase C (NatC) Complex

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